HAI Book 2025 - Flipbook - Page 106
Villemagne, Victor
4
Astrogliosis, a potential non-Aβ pathway to tau
Victor L Villemagne1, Ann D Cohen1, Brian J Lopresti2, Anum Saeed4, Dana Tudorascu1,
Alexandra Gogola2, Cristy Matan2, Alexandria Reese2, Beth E Snitz3, Milos D Ikonomovic3,
Steven E Reis4, Lenore Launer5, Oscar L Lopez3
1
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, US
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, US
3
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, US
4
Heart and Vascular Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA, US
5
Laboratory of Epidemiology & Population Sciences, National Institute of Aging, Bethesda, MD, US
2
Background: In Alzheimer9s disease (AD), widespread cortical A´ deposition usually precedes PET-detectable
cortical tau. A few PET imaging studies reported high cortical tau (T+) in ~2-15% of cases with low A´ (A-) PET, but
some of these individuals were deemed
