HAI Book 2025 - Flipbook - Page 266
Chao, Yishu
Correlation between in vivo 18F-flortaucipir PET and whole brain
postmortem histological tau signals in Alzheimer9s Disease
Yishu Chao1, Yuheng Chen2, Trevor A. Chadwick1, Theresa M. Harrison1, Helmut Heinsen3,
Daniela Ushizima4, Duygu Tosun2, William J. Jagust1, Lea T. Grinberg2
1
University of California Berkeley, Berkeley, CA, US
University of California San Francisco, San Francisco, CA, US
3
University of Würzburg, Würzburg, DE
4
Lawrence Berkeley National Laboratory, Berkeley, CA, US
2
Background: Studies correlating in vivo FTP signals with postmortem immunohistochemical (IHC) assessments
are often limited by their methods, either using qualitative approaches or comparing limited ROIs. We created
whole-brain, quantitative AD-tau density heatmaps to investigate which AD-related tau subtype correlates best
with FTP signal in vivo and regional differences in correlation strength.
Methods: We processed two human brains (Case1 neuropathologic change score: A2B2C1; Case2: A3B3C3)
through our deep-learning histology pipeline to generate 3D tau density heatmaps for 3 tau antibodies: AT8 (p-tau
S202/205), AT100 (p-tau Th212/214), and MC1 (conformational change). Heatmaps and FTP-PET were coregistered
to postmortem MRIs. Heatmaps were smoothed to 6mm isotropic resolution, matching that of FTP-PET. FTP-PET
was inferior cerebellar gray normalized. SUVRs and histological signals were displayed at the voxel level and
averaged in Desikan-Killiany ROIs. We compared signal intensities between cases with paired Welch9s t-tests,
correlated ROI-wise and voxel-wise FTP and histological signals with Spearman9s rank correlation and Pearson
correlation, respectively.
HAI2025 - 266
