HAI Book 2025 - Flipbook - Page 323
Petersen, Kellen
66
A plasma clock for Alzheimer disease based on %p-tau217
Kellen K. Petersen1, Marta Milà-Alomà2,3, Duygu Tosun2,3, Yan Li1, Leslie M. Shaw4, Jeffrey L.
Dage5,6, Henrik Zetterberg7,8,9,10,11,12, Benjamin Saef1, David M. Holtzman1, John C. Morris1,
Chengjie Xiong1,13, Randall J. Bateman1, Anthony W. Bannon14, William Z. Potter15, Suzanne E.
Schindler1
1
Department of Neurology, Washington University in St. Louis, St. Louis, MO, US
Northern California Institute for Research and Education, San Francisco, CA, US
3
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, US
4
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania,
Philadelpia, PA, US
5
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, US
6
Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, US
7
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy
at University of Gothenburg, Mölndal, SE
8
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, SE
9
UK Dementia Research Institute Fluid Biomarkers Laboratory, UK DRI at UCL, London, GB
10
Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, GB
11
Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Units 1501-1502, 1512-1518, 15/F Building 17W, 17
Science Park W Ave, Science Park, Hong Kong, CN
12
Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health,
University of Wisconsin-Madison, Madison, WI, US
13
Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, US
14
AbbVie, Chicago, IL, US
15
Highly qualified expert, Philadelphia, PA, US
2
Background: Amyloid PET-based time proxies have provided valuable insights into the timing of biomarker and
clinical changes in Alzheimer disease (AD). However, compared to PET imaging, collection of blood is much more
accessible and a
