HAI Book 2025 - Flipbook - Page 341
Mundada, Nidhi
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Enrichment of patients with concomitant LATE on the Alzheimer9s
disease continuum using hippocampal volume
Nidhi Mundada1, Xueying Lyu1, Niyousha Sadeghpour1, Christopher Brown1, Emily McCrew1,
Long Xie1, Paul Yushkevich1, Sandhitsu Das1, David Wolk1
1
University of Pennsylvania, Philadelphia, PA, US
Objective: We aimed to identify patients along the AD continuum enriched for concomitant Limbic-predominant
age-related TDP-43 encephalopathy (LATE) by defining the lower quartile of hippocampal volume (HV) as a
biomarker for possible LATE and AD and explore atrophy pattern differences.
Methods: 164 cognitively impaired participants from ADNI with T1-MRI, amyloid-PET, and tau-PET within 365 days
were grouped based on HV quartiles (adjusted for age/intracranial volume) and amyloid status into suspected 1)
AD-only (HV>50th-percentile, amyloid-positive), 2) LATE-only (HV
