HAI Book 2025 - Flipbook - Page 345
Lopresti, Brian
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AT(N) staging of Alzheimer9s disease: Comparison of visual
interpretation and automated quantification pipelines
Brian Lopresti1, Ann Cohen2, Alex DelBene1, Alexandria Reese1, Cristy Matan1, Alexandra
Gogola1, Michelle Chiang1, Beth Snitz3, Sarah Royse1, Oscar Lopez3, Victor Villemagne2
1
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
3
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
2
Background: Biomarker standardization methods for PET A´ (Centiloids, CL) and tau (CenTauRz, CTRz) load in
Alzheimer9s disease (AD) are used in AT(N) staging. Without post-mortem confirmation, visual interpretation is a
practical
20 for
A, CTRz>1.5 for T-MTL, CTRz>2 for T-NEO, and CCT
