HAI Book 2025 - Flipbook - Page 349
Mroué, Rayan
75
Association between medication use and [18F]MK6240 and
[18F]Flortaucipir uptake across the Alzheimer's disease spectrum
Rayan Mroué1, Pamela Lukasewicz Ferreira1, Guilherme Povala1, Bruna Bellaver1, Guilherme
Bauer-Negrini1, Firoza Lussier1, Livia Amaral1, Marina Scop Medeiros1, Emma Ruppert1,
Andreia Silva da Rocha1, Matheus Scarpatto Rodrigues1, Markley Silva Oliveira1, Carolina
Soares Katz1, Douglas Teixeira Leffa1, Pampa Saha1, Cynthia Felix1, Joseph Masdeu2, David
Soleimani-Meigooni3, Juan Fortea4, Val Lowe5, Hwamee Oh6, Belen Pascual2, Brian A.
Gordon7, Pedro Rosa-Neto8, Suzanne Baker9, Tharick A. Pascoal1
1
University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, US
Houston Methodist Research Institute, Department of Neurology, Houston, TX, US
3
University of California San Francisco, Memory and Aging Center, San Francisco, CA, US
4
Hospital de la Santa Creu i Sant Pau, Sant Pau Memory Unit, Department of Neurology, Barcelona, ES
5
Mayo Clinic, Department of Radiology, Rochester, MN, US
6
Brown University, Department of Psychiatry and Human Behavior, Providence, RI, US
7
Washington University in St. Louis, Department of Radiology, St. Louis, MO, US
8
Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research
Institute, Montréal, QC, CA
9
Lawrence Berkeley National Laboratory, Berkeley, CA, US
2
Background: Quantifying tau aggregates in the human brain can be achieved using Positron Emission
Tomography (PET) techniques, which can potentially be affected by binding competition due to medication use.
Patients with dementia often have high rates of comorbidities and polypharmacy. Therefore, this study aims to
investigate the potential influence of multiple medications on the uptake of the tau tracers MK6240 (MK) and
Flortaucipir (FTP).
Methods: 246 individuals, 140 cognitively unimpaired (CU) A´-negative and 106 cognitively impaired (CI) A´positive, from the HEAD study were included in the analyses (Table 1). Five classes of medications were evaluated:
Anti-Hypertensives, Statins, Anti-Diabetics, Psychoactive drugs, and NSAIDs (Table 2). We compared MK and FTP
SUVR in the Medial Temporal Lobe (MTL) and Neotemporal Cortex (NTC) in individuals on and off medications. The
linear regressions that tested associations were corrected for confounding factors, including age, sex, education,
and MoCA score. Correction for multiple comparisons was applied using the Bonferroni method (adjusted p-value
at 0.00125).
Results: Among CI A´-positive individuals, Anti-Diabetics were associated with lower FTP SUVR in the NTC and
lower MK SUVR in both the MTL and NTC. Psychoactive medications were linked to lower MK SUVR in the MTL. In
CU A´-negative individuals, NSAIDs and Statins were associated with higher SUVR in the NTC for FTP and MK,
respectively. However, none of these associations remained significant after correction for multiple comparisons
(Table 3).
Conclusion: Our findings indicate that there are no significant associations between the use of the medications
studied and MK or FTP uptake when accounting for covariates and applying multiple comparison corrections.
HAI2025 - 349
