HAI Book 2025 - Flipbook - Page 362
Schwarz, Christopher
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Updated public CenTauR pipelines to measure CenTauR, CenTauRZ,
and SUVR tau PET units
Christopher Schwarz1, Antoine Leuzy2,3,4, Vincent Doré5, Victor L. Villemagne6, Cally Xiao7,
Ioannis Pappas7, Scott A. Przybelski1, Carl M. Prakaashana1, Matthew L. Senjem1, Val J. Lowe1,
Jeffrey L. Gunter1, Kejal Kantarci1, Prashanthi Vemuri1, Jonathan Graff-Radford1, Ronald C.
Petersen1, David S. Knopman1, Clifford R. Jack1
1
Mayo Clinic, Rochester, MN, US
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, SE
3
Critical Path for Alzheimer’s Disease (CPAD) Consortium, Critical Path Institute, Tucson, AZ, US
4
Enigma Biomedical Group, Knoxville, KY, US
5
Austin Health, Melbourne, AU
6
University of Pittsburgh, Pittsburgh, PA, US
7
Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC,
University of Southern California, Los Angeles, CA, US
2
Background: The CenTauR project provides universal measurement scales and regions-of-interest (ROIs) for
standardizing tau PET quantification units across tracers and pipelines. At HAI 2024, we released two fully
automated software pipelines on the Global Alzheimer9s Association Interactive Network (GAAIN) CenTauR
website (https://www.gaain.org/centaur-project) to compute numeric CenTauRZ and CenTauR SUVR values for
input pairs of T1-w MRI and late-uptake summed tau PET NIfTI files from 6 different tracers: FTP (AV-1451), MK6240, RO948, GTP1, PI2620, or PM-PBB3, with 5 different CenTauR regions of interest (ROIs): universal (global),
mesial temporal, meta-temporal, temporoparietal, and frontal. CenTauRZ units use a Z-score approach to allow
binary classification (+/-) of images from across all these tau PET tracers, using a common threshold. The first
pipeline implements the SPM8-based
