HAI Book 2025 - Flipbook - Page 379
Khurelbaatar, Bayarjargal
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Differential tau accumulation in early-onset and late-onset
Alzheimer's disease: Insights from [18F]-Florzolotau PET
Bayarjargal Khurelbaatar1, Shao-Yi Huang1, Kun-Ju Lin1,2, Chin-Chang Huang3, Jung-Lung
Hsu3, Kuo-Lun Huang3, Hsiu-Chuan Wu3, Chi-Wei Huang4, Chiung-Chih Chang4, Ing-Tsung
Hsiao1,2
1
Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ROC., Taoyuan,
TW
2
Molecular Imaging Center and Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Taoyuan,
TW
3
Neurology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC., Taoyuan, TW
4
Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC., Kaohsiung, TW
Objective: We investigated the longitudinal changes in cortical tau accumulations and their correlation in
different brain regions among patients in the Alzheimer9s disease (AD) continuum using [18F]-Florzolotau PET.
Methods: This study included 55 participants (age 69.8±2.3 y; 22 men, 33 women): 18 with mild cognitive
impairment (MCI), and 37 with Alzheimer's disease (AD). All participants completed [18F]-Florzolotau PET and [18F]Florbetapir PET, MRI, and neuropsychological tests at baseline and after follow-up. Amyloid-´ (A´) PET images
were visually scored as positive (+) or negative (-). Patients on the AD continuum, including A´+ MCI and AD, were
classified into early-onset (EO+
