HAI Book 2025 - Flipbook - Page 415
Results: The voxel-wise mean absolute error for cortical thickness prediction across 40 test patients was 0.38
mm, with an average correlation (rho) of 0.80 (±0.1) between predicted and actual thickness across the brain. Tau
correlated more strongly with predicted than actual thickness, especially in regions with high tau deposition
(Figure 2). Additionally, the model incorporating amyloid displayed stronger tau-thickness correlations than
without amyloid, suggesting greater reliance on AD molecular pathology for N prediction. A global mismatch
metric, derived from reconstruction error, was significantly associated with worse cognition and increased white
matter hyperintensities, but not with global tau levels, suggesting sensitivity to non-AD modulators of N (Figure 3).
Conclusion: The AT-N mismatch, captured through image translation, was linked to clinical and pathological
features. Future work will refine this approach for broader clinical application.
HAI2025 - 415
