HAI Book 2025 - Flipbook - Page 43
11:55 am
12:10 am
12:25 am
Mapping spatial white matter integrity linked
to tau accumulation: Insights from
tractometry with multi-shell diffusion imaging
Spatial patterns of voxel-wise tau
accumulation across the Alzheimer9s disease
spectrum
PET astroglia and microglia follow tau
propagation patterns in Alzheimer9s Disease
12:40 pm - 01:00 pm
Discussion
01:00 pm - 02:00 pm
Lunch break
02:00 pm - 02:30 pm
KEYNOTE: From click chemistry to precision
neuroscience
02:30 pm - 02:45 pm
Keynote Discussion
Dana Parker, University of California Irvine,
Irvine, CA, US
Corrina Fonseca, Department of Neuroscience,
University of California Berkeley, Berkeley, CA,
US
Nesrine Rahmouni, McGill University, Montreal,
QC, CA
Hartmuth Kolb, Enigma Biomedical Group
02:45 pm - 04:25 pm
SESSION III Neuropath I
Tobey Betthauser, University of Wisconsin
School of Medicine and Public Health, Madison,
WI, USA
Teresa Gomez-Isla, Massachusetts General
Hospital, Boston, MA, USA
02:45 pm - 02:50 pm
Session Overview
Chairs
2:50 pm
Correlation between in vivo 18F-flortaucipir
PET and whole brain postmortem histological
tau signals in Alzheimer9s Disease
Yishu Chao, University of California Berkeley,
Berkeley, CA, US
3:05 pm
Tau-PET, structural MRI, and cognitive
measures are differentially correlated with
tangle and neuritic pathology across the
neurofibrillary tangle lifespan
Christina Moloney, Department of Neuroscience,
Mayo Clinic, Jacksonville, FL, US
3:20 pm
Binding of [3H]MK-6240 to different tau
lesions: a brain autopsy study
Milos Ikonomovic, University of Pittsburgh
School of Medicine, Department of Psychiatry,
Pittsburgh, PA, US
3:35 pm
Plasma extracellular vesicle TDP-43 and
hippocampal volume as complementary
biomarkers for LATE-NC and hippocampal
sclerosis: a pathologic validation study
Michel Grothe, Reina Sofia Alzheimer Center,
CIEN Foundation, ISCIII, Madrid, ES
3:50 pm
Discovery and preclinical development of
[18F]ACI-19626, a first-in-class TDP-43 PET
tracer
Francesca Capotosti, AC Immune SA, EPFL
Innovation Park, Building B, Lausanne, CH
04:05 pm - 04:25 pm
Discussion
04:25 pm - 04:30 pm
Blitz Session 1B Short Poster Presentations
04:25 pm
Introduction
04:27 pm
Pathological asymmetry in early onset AD
reflects heterogenous disease trajectories
04:28 pm
Functional submodules in the human locus
coeruleus are differentially susceptible to tau
pathology
HAI2025 - 43
Jacob Ziontz, Memory and Aging Center,
Department of Neurology, University of
California San Francisco, San Francisco, CA, US
Timothy Lawn, Athinoula A. Martinos Center for
Biomedical Imaging, Department of Radiology,
Massachusetts General Hospital and Harvard
Medical School, 02129, Boston, MA, USA, Boston,
MA, US
