HAI Book 2025 - Flipbook - Page 432
Jacobson, David
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Assessing neuroinflammation in Alzheimer's disease: A TSPO-PET
study using ER176 and its correlation with amyloid and tau pathology
Mahathi Kandimalla1, David Jacobson1, Seokbeen Lim1, Jeyeon Lee1,3, Hoon-Ki Min1, Hugo
Botha2, Jonathan Graff-Radford2, David Jones2, Prashanthi Vemuri1, Kejal Kantarci1, David
Knopmam2, Clifford Jack1, Ronald Petersen2, Val Lowe1
1
Department of Radiology, Mayo Clinic, Rochester, MN, US
Department of Neurology, Mayo Clinic, Rochester, MN, US
3
Department of Biomedical Engineering, Seoul, KR
2
Objective: Neuroinflammation plays a crucial role in neuronal damage, synaptic dysfunction, and impaired
neurogenesis, significantly contributing to Alzheimer's Disease (AD) progression. In this study, we evaluated
ER176's effectiveness in detecting neuroinflammation across a spectrum of disease with CU A3, CU A+, MCI, and
AD participants, with particular attention to amyloid and tau status.
Methods: Participants from the Mayo Clinic Study of Aging were recruited for this study. The study included four
participant groups: cognitively unimpaired with normal amyloid (CU A3, n=25), cognitively unimpaired with high
amyloid (CU A+, n=25), mild cognitive impairment with increased amyloid (MCI A+, n=25), and AD dementia (AD,
n=15). We explored the variations in Neuroinflammation PET results among different groups.
Results: We conducted surface-based ROI analysis, incorporating age, sex, and rs6971 polymorphism genotype as
covariates. Our results did not indicate significant differences in neuroinflammation between CU A+ and CU A3.
However, when compared to CU A3, both MCI and AD groups displayed significant differences, with AD exhibiting a
broader range of affected areas. No significant difference was observed between MCI and CU A+, while AD
showed significant differences compared to CU A+. Comparing AD to MCI did not reveal significant differences.
The comparison of amyloid-positive and amyloid-negative groups showed significant differences (Figure 1a). The
comparison between tau-positive (tau>=1.29) and tau-negative (tau
