HAI Book 2025 - Flipbook - Page 45
11:35 am
11:50 am
12:05 am
Tau-related cortical thinning is concentrated
in sulcal depths
Comparison of [3H]MK-6240 and [3H]AV-1451
binding in relation to brain concentrations of
p-tau: A postmortem biochemistry study
In vitro binding of the tau PET tracer
[3H]JSS20-183A and its comparison with PI2620, T807 and PM-PBB3 in human
postmortem brain tissue
12:20 pm - 12:40 pm
Discussion
12:40 pm - 01:40 pm
Lunch break
01:40 pm - 02:10 pm
KEYNOTE: From neuropathology to
biomarkers: Novel strategies for detecting
and monitoring Early Alzheimer9s disease in
vivo
02:10 pm - 02:25 pm
Keynote Discussion
Samira Maboudian, Department of
Neuroscience, University of California, Berkeley,
Berkeley, CA, US
Tobey Betthauser, University of WisconsinMadison, School of Medicine and Public Health,
Department of Medicine, Madison, WI, US
Dinahlee Saturnino Guarino, Department of
Radiology, University of Pennsylvania,
Philadelphia, PA, US
Lea Grinberg, University of California, San
Francisco, San Francisco, CA, USA
02:25 pm - 03:50 pm
SESSION V Clinically Relevant Applications
Renaud La Joie, University of California, San
Francisco, San Francisco, CA, USA
Reisa Sperling, Brigham and Women's
Hospital/HMS, Boston, MA, USA
02:25 pm - 02:30 pm
Session Overview
Chairs
2:30 pm
2:45 pm
Neuropathologic and ARIA-related findings in
aducanumab-treated Alzheimer's disease: a
postmortem analysis of superficial cortical A´
clearance
Robustness of the centiloid scale across
research and commercial software using
[18F]flutemetamol PET images
3:00 pm
Impact of ARIA on cerebral volume changes
with Gantenerumab
3:15 pm
Independent effects of baseline white matter
hyperintensity and APOE ɛ4 on future ARIA-H
emergence in A4 trial
03:30 pm - 03:50 pm
Discussion
03:50 pm - 03:55 pm
Blitz Session 2B Short Poster Presentations
3:50 pm
Introduction
3:52 pm
3:53 pm
3:54 pm
Baayla Boon, Department of Neuroscience,
Jacksonville, FL, US
Adam Schwarz, GE HealthCare, Chalfont St.
Giles, GB
Matteo Tonietto, Research and Early
Development (pRED), Hoffmann-La Roche,
Basel, CH
Zahra Shirzadi, Department of Neurology,
Massachusetts General Hospital, Brigham and
Women's Hospital, Harvard Medical School,
Boston, MA, US
Cortical freewater increases with tau tangle
aggregation
Brandon Hall, McGill University, Montreal, QC, CA
Two distinct sources of 18F-MK-6240 offtarget signal identified by individualized head
modeling and PET kinetics
Tracking plasma biomarker abnormalities with
amyloid time accumulation
Charles Chen, Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General
Hospital, Charlestown, MA, US
Marina Bluma, Karolinska Institutet, Department
of Neurobiology, Care Sciences and Society,
HAI2025 - 45
