HAI Book 2025 - Flipbook - Page 458
Thursday, January 16, 2025 - 01:40 pm - 02:10 pm
Grinberg, Lea
Keynote: From neuropathology to biomarkers: Novel strategies for detecting and
monitoring Early Alzheimer9s disease in vivo
Grinberg, Lea
University of California, San Francisco
Neuropathology has revealed key insights into Alzheimer9s
disease (AD) that have driven biomarker discovery, enabling
the detection and, to some extent, monitoring of AD
hallmarks in vivo. This talk will delve into neuropathological
observations that represent underexplored opportunities
for biomarker development, focusing on those with the
potential to enable even earlier detection and monitoring.
By bridging tissue-based discoveries with imaging and fluid
biomarkers, modern neuropathology is well positioned to
address gaps in current biomarker development strategies
and improve the early diagnosis and tracking of
neurodegenerative conditions.
Dr. Lea Tenenholz Grinberg is a neuropathologist
specializing in brain aging and associated
disorders, most notably, Alzheimer’s and
neurological basis of sleep disturbances in
neurodegenerative diseases.
Currently, she is a Full Professor and a John
Douglas French Alzheimer’s Foundation
Endowed Professor at the UCSF Memory and
Aging Center, part of the Executive Board of the
Global Brain Health Institute and member of the
Medical Scientific Advisory Group for the
Alzheimer Association. She is also a Professor
of Pathology at the University of Sao Paulo.
In 2003, Dr. Grinberg was among the founders of
a brain bank in São Paulo, focusing on brain
aging. This brain bank which she had since
developed into an extremely prolific and highly
regarded institution, helped Dr. Grinberg prove
that contrary to what has been accepted
previously, the brainstem and not the cortex,
harbors the first detectable neurodegeneration
in Alzheimer’s disease. In 2009, she was the
recipient of the UNESCO-L’Oréal Award