HAI Book 2025 - Flipbook - Page 547
Ramirez Tirado, Laura Alejandra
121
Synergistic effects of peripheral inflammation and
neuroinflammation on amyloid, vascular, and neurodegeneration markers
across the Alzheimer9s disease spectrum
Laura Alejandra Ramirez Tirado1, Ann D Cohen2,3, C Elizabeth Shaaban1,3, Cristy Matan4, Brian
J Lopresti4, Milos D Ikonomovic3,5, Thomas K Karikari2,3, Victor L Villemagne2,3, Oscar L
Lopez3,5
1
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, US
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, US
3
Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, PA, US
4
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, US
5
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, US
2
Systemic inflammation and astrogliosis are relevant in Alzheimer9s disease (AD). We evaluated whether peripheral
inflammation has synergistic effects with astrogliosis on ´-amyloid (A´), vascular, and neurodegeneration
markers.
In the Ginkgo Evaluation of Memory Study, we evaluated the relationship between peripheral inflammation (TNFR1, TNF-R2, IL-6, IL-2, CRP and sCD14) and astrogliosis (GFAP
