HAI Book 2025 - Flipbook - Page 562
Winer, Joseph
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Short sleep duration is associated with higher subsequent plasma
p-tau217 in aging
Joseph Winer1, Karly Cody1, Christina Young1, Elizabeth Mormino1,2
1
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, US
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, US
2
Background: Short sleep duration is associated with elevated amyloid PET burden, but the impact of sleep
duration on subsequent biomarker changes is not well understood. We sought to determine whether baseline
sleep duration was predictive of longitudinal plasma and imaging biomarkers in cognitively unimpaired older
adults.
Methods: We examined 1418 initially unimpaired participants (1071 A+, 347 A-) from the A4/LEARN study with Lilly
plasma p-tau217, MRI, and self-reported sleep duration (Table). FLAIR MRI was used to quantify white matter
hyperintensity (WMH) volume, corrected for intracranial volume. Linear mixed-effects models (random intercept)
were used to assess the association between baseline sleep duration and longitudinal change in biomarkers.
Models included baseline sleep duration (f6, 7-8, or g9 hours), baseline age, baseline amyloid PET SUVR, and sex
and their interactions with time.
Results: Participants were followed for an average of 3.9 ± 2.3 years. Short sleep duration (f6 hours) at baseline
was associated with greater subsequent increase in plasma p-tau217 compared to normal sleep, independent of
baseline amyloid PET SUVR (´=0.03 ± 0.009, p=0.004; Figure 1A). Both short and long (g9 hours) sleep durations
were associated with greater subsequent increases in WMH volume compared to normal sleep, independent of
baseline amyloid PET SUVR (short, ´=0.08 ± 0.03, p=0.004; long, ´=0.17 ± 0.06, p=0.003; Figure 1B).
Conclusions: In this longitudinal study, short sleep was associated with greater increase in AD pathology
measured with plasma p-tau217, while both short and long sleep were associated with greater increase in WMH
volume, suggesting adequate sleep is important for healthy aging trajectories via multiple pathways.
HAI2025 - 562
