HAI Book 2025 - Flipbook - Page 58
Assessing neuroinflammation in Alzheimer's
disease: A TSPO-PET study using ER176 and its
correlation with amyloid and tau pathology
Two distinct sources of 18F-MK-6240 off-target
signal identified by individualized head modeling
and PET kinetics
Characterizing fluid and cortical tau biomarker
expression in typical and atypical Alzheimer's
disease: A comparative study of pTau levels and
tau-PET imaging
TSPO PET mediates tau-associated
neurodegeneration in limbic and temporal
regions across clinical variants of Alzheimer9s
disease
White matter microstructural degeneration is
spatially correlated with tau accumulation in
Autosomal Dominant Alzheimer disease
Tracking plasma biomarker abnormalities with
amyloid time accumulation
Advancing antibody-based pretargeted PET
imaging of protein aggregates in the brain
Longitudinal change in mnemonic
discrimination and influence of A´ burden
David Jacobson, Department of Neurology,
Mayo Clinic, Rochester, MN, US
Charles Chen, Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General
Hospital, Charlestown, MA, US
Delphine Oliva-Lopez, Montreal Neurological
Institute, Montreal, QC, CA
Patrick Lao, Columbia University Medical
Center, New York, NY, US
Nicole McKay, Washington University School of
Medicine, St. Louis, MO, US
Marina Bluma, Karolinska Institutet, Department
of Neurobiology, Care Sciences and Society,
Division of Clinical Geriatrics, Center of
Alzheimer Research, Stockholm, SE
Michael Honer, Cluster for Molecular Imaging,
Department of Biomedical Sciences, University
of Copenhagen, Copenhagen, DK
Jessica Kraft, Center for Vital Longevity,
University of Texas at Dallas, Dallas, TX, US
11:00 am - 12:40 pm
SESSION IV Neuropath II
Keith Johnson, Massachusetts General Hospital,
Boston, MA, USA
Christina Moloney, Mayo Clinic, Jacksonville, FL,
USA
11:00 am - 11:05 am
Session Overview
Chairs
11:05 am
11:20 am
11:35 am
11:50 am
12:05 am
Understanding the mechanisms of synaptic
vesicle glycoprotein 2A change in Alzheimer's
disease
Association of [18F]Flortaucipir-PET and plasma
p-tau217 with tau neuropathology in AD and
other neurodegenerative disorders
Tau-related cortical thinning is concentrated in
sulcal depths
Comparison of [3H]MK-6240 and [3H]AV-1451
binding in relation to brain concentrations of ptau: A postmortem biochemistry study
In vitro binding of the tau PET tracer
[3H]JSS20-183A and its comparison with PI2620, T807 and PM-PBB3 in human postmortem
brain tissue
12:20 pm - 12:40 pm
Discussion
12:40 pm - 01:40 pm
Lunch break
01:40 pm - 02:10 pm
KEYNOTE: From neuropathology to
biomarkers: Novel strategies for detecting and
monitoring Early Alzheimer9s disease in vivo
HAI2025 - 58
Laetitia Lemoine, Perceptive, London, GB
Agathe Vrillon, University of California San
Francisco, San Francisco, CA, US
Samira Maboudian, Department of
Neuroscience, University of California, Berkeley,
Berkeley, CA, US
Tobey Betthauser, University of WisconsinMadison, School of Medicine and Public Health,
Department of Medicine, Madison, WI, US
Dinahlee Saturnino Guarino, Department of
Radiology, University of Pennsylvania,
Philadelphia, PA, US
Lea Grinberg, University of California, San
Francisco, San Francisco, CA, USA
