HAI Book 2025 - Flipbook - Page 581
Gogola, Alexandra
134
Tau imaging thresholds within NIA-AA multilevel tau staging as
predictors of tau accumulation and cognitive decline in non-demented
individuals
Alexandra Gogola1, Ann Cohen2,3, Beth Snitz3,4, Davneet Minhas1, Dana Tudorascu2,3, Milos
Ikonomovic3,4,8, C. Elizabeth Shaaban3,5,8, Vincent Dore6,7, Cristy Matan1, Alexander DelBene1,
Pierrick Bourgeat7, Antoine Leuzy9, Howard Aizenstein2,3, Oscar Lopez3,4, Brian Lopresti1,
Victor Villemagne2,3,6
1
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, US
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, US
3
Alzheimer’s Disease Research Center, University of Pittsburgh, Pittsburgh, PA, US
4
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, US
5
Department of Epidemiology, Pittsburgh, PA, US
6
Department of Molecular Imaging & Therapy, Austin Health, Melbourne, AU
7
Commonwealth Scientific and Industrial Research Organisation Health & Biosecurity, Melbourne, AU
8
Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA,
US
9
Critical Path for Alzheimer’s Disease (CPAD) Consortium, Critical Path institute, Pittsburgh, PA, US
2
Background: We evaluated the predictive performance of 18F-flortaucipir (FTP) tau imaging with respect to tau
accumulation and cognitive decline in non-demented participants. We also tested the relationships between
baseline tau and tau accumulation in relation to different cognitive measures.
Methods: FTP scans from 213 non-demented participants were processed and sampled in Statistical Parametric
Mapping software (SPM), version 8, using CenTauR masks. Tau accumulation and cognitive decline associations
were assessed longitudinally, with respect to their baseline and most recent evaluations, via survival analysis.
Individuals were grouped into 4 groups reflecting the NIA-AA imaging stages: Initial, Early, Intermediate, and
Advanced. A
