HAI Book 2025 - Flipbook - Page 624
Pascual, Belen
148
Anatomic specificity of inflammation TSPO PET biomarkers in
dementia
Quentin Finn1, Alireza Faridar1, Jon B Toledo1, Obadah Nakawah1, Gustavo Roman1, Joseph C
Masdeu1, Belen Pascual1
1
Houston Methodist Research Institute, Weill Cornell Medicine, Houston, TX, US
Background: Brain inflammation, a hallmark of neurodegeneration and a potentially important therapeutic target,
can be measured in vivo with translocator protein 18 kDa (TSPO) PET. Tracers bind to microglia and migrated
macrophages. 11C-PBR28 and 11C-ER176