HAI Book 2025 - Flipbook - Page 629
Soares, Carolina
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Characterization of PART using MK-6240, Flortaucipir, and plasma
p-tau217
Carolina Soares1, Pamela L. Ferreira1, Emma Ruppert1, Marina S. Medeiros1, Andreia Rocha1,
Bruna Bellaver1, Guilherme Povala1, Guilherme Bauer-Negrini1, Livia Amaral1, Madeleine
Bloomquist1, Firoza Lussier1, Joseph Masdeu2, Dana L. Tudorascu1, David SoleimaniMeigooni4, Juan Fortea5, Val Lowe6, Hwamee Oh7, Belen Pascual2, Brian A. Gordon8, Pedro
Rosa-Neto9, Suzanne Baker3, Tharick A. Pascoal1
1
University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, US
Houston Methodist Research Institute, Department of Neurology, Houston, TX, US
3
Lawrence Berkeley National Laboratory, Berkeley, CA, US
4
University of California San Francisco, Memory and Aging Center, San Francisco, CA, US
5
Hospital de la Santa Creu i Sant Pau, Department of Neurology, Barcelona, ES
6
Mayo Clinic, Department of Radiology, Rochester, MN, US
7
Brown University, Department of Psychiatry and Human Behavior, Providence, RI, US
8
Washington University in St. Louis, Department of Radiology, St. Louis, MO, US
9
Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research
Institute, Montreal, QC, CA
2
Older adults with brain tau pathology(T) but no evident amyloid-´(A) pathology can be referred to as primary agerelated tauopathy(PART).However, in vivo characterization of PART using biomarkers remains unclear, varying
based on the method used to define tau pathology(e.g.,fluid or different tau PET tracers). We conducted a headto-head characterization of PART using two different tau PET tracers and plasma p-tau217.
We studied 345(185 cognitively unimpaired (CU),115 mild cognitively unimpaired (MCI),45 dementia)individuals from
the HEAD cohort where all subjects had clinical assessments, MRI, A-PET, and both MK-6240 and Flortaucipir
scans in the same visit, and a subset with plasma p-tau217 (n=330).Individuals were conservatively classified as A´
PET positive (visual readings). Additionally, individuals were classified as tau-positive if their tau PET standard
uptake value ratio (SUVR) values in Braak 1 region or plasma p-tau217 levels were above the mean + 2 SD from CU
A- individuals. PART individuals were defined as A-T+, and concordance across biomarkers was assessed.Voxelwise analysis were used to estimate percentage of abnormal voxels.
We found 29(8.40 %) cases of individuals classified as A-T+ (73±7.5 years, 38% females, 17 CU, 10 MCI, 2
dementia).Detection of A-T+ cases varied: Flortaucipir (n=10), MK-6240 (n=14), plasma p-tau217 (n=14).
Concordance between biomarkers was low, with the highest overlap (n=4, 14%) between MK-6240 and Flortaucipir
(Fig.1A). Interestingly, the number of A-T+ individuals with dementia detected with MK-6240, Flortaucipir and
plasma p-tau217, respectively, was 4, 2 and 0 (Fig.1B).
HAI2025 - 629
