HAI Book 2025 - Flipbook - Page 654
Rocha, Andreia
158
Harmonization of MK6240 and Flortaucipir Braak Staging
Andreia Rocha1, Bruna Bellaver1, Emma Ruppert1, Pamela L. Ferreira1, Carolina Soares1,
Marina Medeiros1, Guilherme Povala1, Livia Amaral1, Guilherme Bauer-Negrini1, Firoza Lussier1,
Matheus Scarpatto Rodrigues1, Markley Oliveira Jr.1, Pampa Saha1, Maddie Bloomquist1,
Joseph Masdeu2, Dana L. Tudorascu1, David Soleimani-Meigooni3, Juan Fortea4, Val Lowe5,
Hwamee Oh6, Belen Pascual2, Brian A. Gordon7, Pedro Rosa-Neto8, Suzanne Baker9, Tharick A.
Pascoal1
1
University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, US
Houston Methodist Research Institute, Department of Neurology, Houston, TX, US
3
University of California San Francisco, Memory and Aging Center, San Francisco, CA, US
4
Hospital de la Santa Creu i Sant Pau, Sant Pau Memory Unit, Department of Neurology, Barcelona, ES
5
Mayo Clinic, Department of Radiology, Rochester, MN, US
6
Brown University, Department of Psychiatry and Human Behavior, Providence, RI, US
7
Washington University in St. Louis, Department of Radiology, St. Louis, MO, US
8
Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research
Institute, Montréal, QC, CA
9
Lawrence Berkeley National Laboratory, Berkeley, CA, US
2
Background: In vivo Braak staging effectively stratifies patients across the AD spectrum and has the potential to
harmonize tau PET tracer assessment. This study aims to compare and test harmonization procedures for Braak
staging individuals using MK6240 and Flortaucipir tau PET tracers.
Method: We assessed 378 individuals across the AD continuum (213 CU, 119 MCI, 46 dementia; age = 68.5 ± 8.6) with
MK6240 and Flortaucipir scans. Standardized uptake value ratios (SUVRs) were calculated in Braak regions. We
tested two cut-off methods to regional positivity: (a) Mean + 2.5 SD of young individuals (age = 22.9 ± 1.7) (b) Mean +
2.5 SD of CU Elderly A´- individuals (age = 65.2 ± 8.4; Centiloid
