HAI Book 2025 - Flipbook - Page 658
Results: Clinical stages showed a progressively increased prevalence of A´+ and entorhinal tau PET pathology
from cognitively normal (CN) to SOCD, MCI, and dementia. MBI and SCD transitional groups showed no increased
A´+ or tau pathology compared to CN (Figure 1A, B). For this reason, only SOCD was considered part of stage 2 for
further analyses. All tested biological staging methods had similar agreement with clinical stages using MK-6240
and Flortaucipir (Figure 3A). All strategies showed reasonable between-tracer concordance (K>0.60), with AA2024 and single-region strategies showing the best agreements (72-73%) and Braak-staging showing the worse
(65-67%) (Figure 3B).
HAI2025 - 658
