HAI Book 2025 - Flipbook - Page 668
Saukkonen, Daniel
162
Posterior white matter hyperintensity is related to the emergence
of lobar cerebral microbleeds in ADNI
Daniel Saukkonen1, Hyun-Sik Yang1, Nazila Loghmani1, Aaron Schultz2, Steven Greenberg2,
Reisa Sperling1,2, Jasmeer Chhatwal1,2, Zahra Shirzadi1,2
Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US
1
2
Background: Cerebral amyloid angiopathy (CAA) is clinically characterized by identifying cerebral microbleeds
(CMBs). Recent evidence showed that white matter hyperintensity (WMH) may also be related to CAA
pathophysiology. This study investigated the regional pattern of WMH in CAA by examining the relationship
between lobar WMH and CMBs cross-sectionally and longitudinally in the spectrum of AD using the Alzheimer9s
Disease Neuroimaging Initiative (ADNI) dataset.
Methods: We extracted WMH from FLAIR MRI for 571 participants in ADNI, with clinical and neuroimaging data
collected between 2007 and 2021. Each participant had at least one follow-up MRI and clinical assessment. CMBs
were identified by experienced radiologists at Mayo Clinic and categorized as 8No CAA9 (0 CMB), 8Possible CAA9 (1
CMB), and 8Probable CAA9 (g2 CMBs) based on Boston criteria. Cross-sectional analysis used linear regression to
assess the relationship between lobar WMH and CAA categories, adjusting for age, sex, grey matter volume,
vascular risk, and APOE e4 (p
