HAI Book 2025 - Flipbook - Page 9
comparative study of pTau levels and tauPET imaging ....................................... 437
Lao, Patrick........................................ 438
112 TSPO PET mediates tau-associated
neurodegeneration in limbic and temporal
regions across clinical variants of
Alzheimer9s disease ............................. 438
McKay, Nicole ..................................... 440
In vitro binding of the tau PET tracer
[3H]JSS20-183A and its comparison with
PI-2620, T807 and PM-PBB3 in human
postmortem brain tissue ......................457
Thursday, January 16, 2025 - 01:40 pm - 02:10 pm ... 458
Grinberg, Lea ..................................... 458
Keynote: From neuropathology to biomarkers:
Novel strategies for detecting and monitoring
Early Alzheimer9s disease in vivo ................ 458
113 White matter microstructural
degeneration is spatially correlated with
tau accumulation in Autosomal Dominant
Alzheimer disease ............................... 440
Thursday, January 16, 2025 - 02:25 pm - 03:50 pm .. 459
Podium Session ....................................................... 459
114 Tracking plasma biomarker
abnormalities with amyloid time
accumulation ....................................... 441
Neuropathologic and ARIA-related ondings
in aducanumab-treated Alzheimer's
disease: a postmortem analysis of
superocial cortical A´ clearance ......... 460
Bluma, Marina ..................................... 441
Honer, Michael ...................................444
115 Advancing antibody-based pretargeted
PET imaging of protein aggregates in the
brain ................................................... 444
Kraft, Jessica .................................... 445
116 Longitudinal change in mnemonic
discrimination and innuence of A´ burden
........................................................... 445
Thursday, January 16, 2025 - 11:00 am - 12:40 pm ..... 446
Podium Session ....................................................... 446
SESSION IV: Neuropath II ............................ 446
Lemoine, Laetitia ............................... 447
Understanding the mechanisms of
synaptic vesicle glycoprotein 2A change in
Alzheimer's disease ............................. 447
Vrillon, Agathe ................................... 448
Association of [18F]Flortaucipir-PET and
plasma p-tau217 with tau neuropathology
in AD and other neurodegenerative
disorders ............................................ 448
Maboudian, Samira ............................ 452
Tau-related cortical thinning is
concentrated in sulcal depths.............. 452
Betthauser, Tobey.............................. 456
Comparison of [3H]MK-6240 and [3H]AV1451 binding in relation to brain
concentrations of p-tau: A postmortem
biochemistry study ............................. 456
Saturnino Guarino, Dinahlee .............. 457
HAI2025 - 9
SESSION V: Clinically Relevant Applications
..................................................................... 459
Boon, Baayla ...................................... 460
Schwarz, Adam .................................. 463
Robustness of the centiloid scale across
research and commercial software using
[18F]nutemetamol PET images ........... 463
Tonietto, Matteo................................. 466
Impact of ARIA on cerebral volume
changes with Gantenerumab ............... 466
Shirzadi, Zahra ................................... 469
Independent effects of baseline white
matter hyperintensity and APOE ɛ4 on
future ARIA-H emergence in A4 trial .... 469
Thursday, January 16, 2025 - 03:50 pm - 03:55 pm....473
Podium Session ........................................................473
Blitz Session 2B: Short Poster Presentations
..................................................................... 473
Hall, Brandon ...................................... 474
Cortical freewater increases with tau
tangle aggregation...............................474
Chen, Charles ..................................... 477
Two distinct sources of 18F-MK-6240 offtarget signal identioed by individualized
head modeling and PET kinetics ........... 477
Bluma, Marina .................................... 480
Tracking plasma biomarker abnormalities
with amyloid time accumulation .......... 480
Thursday, January 16, 2025 - 04:50 pm - 06:15 pm ... 483
Podium Session ....................................................... 483
SESSION VI: Heterogeneity ......................... 483
Schultz, Stephanie ............................. 484
